Naproxen sodium is a drug used to relieve pain, fever, swelling and stiffness. It works by inhibiting COX-1 and COX-2 (Cyclooxygenase 1 and 2) enzymes which inhibits prostaglandin synthesis. Prostaglandins act as signalling molecules in the body, inducing inflammation. Thus, by inhibiting COX-1/2, naproxen induces an anti-inflammatory effect. For the determination of naproxen sodium in pharmaceutical dosage form and bulk form, several analytical methods including LC-MS, GC-MS, HPTLC, UV, HPLC and other methods has been developed. Methods indicating human plasma, stability and impurity profiling are also described for naproxen. For qualitative and quantitative estimation of naproxen these analytical methods can be used and it can also be used for its related degradants in bulk formulations and biological fluids. The following study depicts the review on analytical methods which includes estimating the propionic acid derivative, naproxen.
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